Snakeskin is used in the Crafting skill to make snakeskin armour. It can be created by giving a snake hide and 15 coins to a tanner. A tanner can be found in Al-Kharid, Canifis, the Ranging Guild and the Crafting Guild. Tanning swamp snake hide will also result in snakeskin.

Two Snakeskins are also used to turn tribal masks into Broodoo shields. Players can make snakeskins into snakeskin armour components if they have a needle and thread.

Snake hides are dropped by bush snakes on Karamja during the Tai Bwo Wannai Cleanup activity or by a snake with combat level 35 can be found on Mos Le’Harmless, although it is poisonous. The only thing you need to worry about is the poison, which can be negated with an antipoison potion. Additionally, snake hides are dropped by the hoop snakes inhabiting Fossil Island.