Grapes can be produced through planting grape seeds at the Hosidius House Vinery in Great Kourend, requiring level 36 in Farming and 65% favour with the Hosidius House.

They are an ingredient for making a jug of wine at level 35 Cooking by using them on a jug of water, which grants 200 Cooking experience when fermented after a short period. If fermentation fails, a jug of bad wine will be created instead. Players stop creating jugs of bad wine when they reach 68 Cooking.

A bunch of grapes is also required for Monkey Madness II.